The Journal of Neuropsychiatry
& Clinical Neurosciences

Official Journal of the American Neuropsychiatric Association Editor: Stuart C. Yudofsky, M.D.
Deputy Editors: David B. Arciniegas, M.D. and Robert E. Hales, M.D., M.B.A.
REGULAR ARTICLES  |  April 1, 2014
Functional Magnetic Resonance Imaging Study of Apathy in Alzheimer’s Disease

An fMRI study was launched to understand mechanisms of Alzheimer’s disease (AD) patients with apathy. The authors reviewed seven AD patients with apathy and six AD patients without apathy. Under “sad versus neutral” stimulation, non-apathetic AD patients had increased activity in bilateral amygdala and bilateral fusiform gyrus, whereas apathetic AD patients only had increased activities in bilateral fusiform gyrus. Thus, the amygdala was the possible anatomical structure related to apathy in AD patients.

Special Articles  |  April 1, 2014
Systematic Review of Neuroimaging Correlates of Executive Functioning: Converging Evidence From Different Clinical Populations

Executive functioning (EF) is an important cognitive domain that is negatively affected in a number of neuropsychiatric conditions. The authors found that the frontal, parietal, and cerebellar lobes were most frequently associated with EF when comparing results from different clinical populations; the occipital lobe was not correlated with EF in any group.

REGULAR ARTICLES  |  April 1, 2014
Long-Term Neuropsychological Safety of Subgenual Cingulate Gyrus Deep Brain Stimulation for Treatment-Resistant Depression

Deep brain stimulation of the subgenual cingulate gyrus is a promising investigational intervention for treatment-resistant depression (TRD), but long-term outcome data are limited. Serial neuropsychological evaluations, using a comprehensive battery, were conducted on four subjects with TRD prior to surgery, and up to 42 months post-operatively. Reliable change methodology suggested general stability and/or select statistically reliable improvement in cognitive abilities over time.

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