To the Editor: Brain tumors may present with multiple psychiatric symptoms, such as depression, anxiety disorders, panic attacks, personality change, abulia, auditory and visual hallucinations, mania, or memory difficulties. In the present study, we discuss a case of a 50-year-old man who was treated for 7 years for anxiety disorder and depression but did not respond to treatment. At that period, he did not develop any major neurological signs or symptoms. When he complained of headache, he was examined by a neurologist, and MRI scans (MRIs) were performed. MRIs of the brain revealed a glial tumor in the left temporal lobe, and he underwent surgical treatment and subsequently received chemotherapy and radiotherapy.