The authors investigated the combined age and HIV effects on cognitive functions in 146 individuals, 116 of whom had HIV infection. Forty-two percent had HIV-associated neurocognitive disorder, and all were receiving highly active antiretroviral therapy. Using linear and nonlinear regression modeling, the authors found only a trending effect of the quadratic term HIV status × age, both including dementia cases (p=0.12) and excluding dementia cases (p<0.06). Our results suggest that either this early-2000 cohort is not old enough to detect a clear interactive age and HIV effect or that there may be a survivor bias for individuals with long-term infection. Further longitudinal studies are warranted.

Volume 23
Issue 1

Winter 2011
Pages 83-89

Metrics

This study was sponsored by Brain Sciences post-doctoral fellowship at the University of New South Wales, Sydney, Australia. The authors report no conflicts of interest. We thank A/Prof. John Murray at The National Centre in HIV Epidemiology and Clinical Research, and School of Mathematics and Statistics, University of New South Wales, for his helpful comments on the data analysis part and illustrations of the manuscript. We also thank the participants for their time.

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History

Received 18 May 2009

Revised 26 October 2009

Accepted 2 April 2010

Published online 1 January 2011

Published in print 1 January 2011

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HIV and Age Do Not Substantially Interact in HIV-Associated Neurocognitive Impairment

Abstract