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Successful methylphenidate treatment of apathy after subcortical infarcts

Published Online:https://doi.org/10.1176/jnp.7.4.502

A patient with prominent apathy secondary to multiple subcortical infarcts was treated successfully with methylphenidate. SPECT and reaction time testing showed selective improvement of frontal system function, consistent with a recent model of frontal-subcortical circuits and behavior.

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