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The Journal of Neuropsychiatry and Clinical Neurosciences

Volume 32, Issue 4

October 2020

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Windows to the Brain

October 2020

Complex Metal Ions: Neuropsychiatric and Imaging Features

James R. Bateman, M.D., M.P.H.,
Katherine H. Taber, Ph.D.,
Robin A. Hurley, M.D.

Pages:A4–321
Published Online:29 October 2020

https://doi.org/10.1176/appi.neuropsych.20080223

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Special Articles

October 2020

Clinical Application of Findings From Longitudinal Studies of Younger-Onset Dementia: Rapid Review and Recommendations

Samantha M. Loi, Ph.D., F.R.A.N.Z.C.P.,
Anita M. Y. Goh, B.Sc., D.Psych.,
Mark Walterfang, Ph.D., F.R.A.N.Z.C.P.,
Dennis Velakoulis, D.Med.Sc., F.R.A.N.Z.C.P.

Pages:322–333
Published Online:13 May 2020

https://doi.org/10.1176/appi.neuropsych.19110238

Abstract
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Younger-onset dementia (YOD) presents with heterogeneous symptoms, has a variety of etiologies, and can be difficult to diagnose. The authors conducted a rapid review of longitudinal YOD cohorts and their related substudies to evaluate current literature ...

October 2020

Visual Hallucinations and the Role of Medications in Parkinson’s Disease: Triggers, Pathophysiology, and Management

Alice Powell, F.R.A.C.P.,
Catriona Ireland, F.R.A.C.P.,
Simon J.G. Lewis, Ph.D., F.R.A.C.P.

Pages:334–343
Published Online:6 May 2020

https://doi.org/10.1176/appi.neuropsych.19110316

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Visual hallucinations, which are part of the syndrome of Parkinson’s disease (PD) psychosis, affect patients’ quality of life and increase the likelihood of residential aged-care placement. The association between visual hallucinations and dopaminergic ...

October 2020

Speech and Language Therapy for Voice Problems in Parkinson’s Disease: A Meta-Analysis

Hongyan Xu, M.D.,
Zhuohua Bao, M.D.,
Daye Liang, M.D.,
Mengxia Li, M.D.,
Minguang Wei, M.D.,
Xueqing Ge, M.D.,
Jingli Liu, Ph.D.,
Jinpin Li, Ph.D.

Pages:344–351
Published Online:6 May 2020

https://doi.org/10.1176/appi.neuropsych.19020044

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Patients with Parkinson’s disease (PD) commonly have speech and voice problems that affect their functional communication and that are not sensitive to pharmacological or neurosurgical treatments. The authors aimed to evaluate the effects of speech and ...

Regular Articles

October 2020

Comparison of T₁Rho MRI, Glucose Metabolism, and Amyloid Burden Across the Cognitive Spectrum: A Pilot Study

Laura L. Boles Ponto, Ph.D.,
Vincent A. Magnotta, Ph.D.,
Yusuf Menda, M.D.,
David J. Moser, Ph.D.,
Jacob J. Oleson, Ph.D.,
Emily L. Harlynn, B.S.,
Sean D. DeVries, M.S.,
John A. Wemmie, M.D., Ph.D.,
Susan K. Schultz, M.D.

Pages:352–361
Published Online:14 April 2020

https://doi.org/10.1176/appi.neuropsych.19100221

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Objective:The pathological cascades associated with the development of Alzheimer’s disease (AD) have a common element: acidosis. T₁rho MRI is a pH-sensitive measure, with higher values associated with greater neuropathological burden. The authors ...

October 2020

Effect of Functional BDNF and COMT Polymorphisms on Symptoms and Regional Brain Volume in Frontotemporal Dementia and Corticobasal Syndrome

Edward D. Huey, M.D.,
Rachel Fremont, M.D., Ph.D.,
Masood Manoochehri, B.A.,
Yunglin Gazes, Ph.D.,
Seonjoo Lee, Ph.D.,
Stephanie Cosentino, Ph.D.,
Michael Tierney, M.S,
Eric M. Wassermann, M.D.,
Parastoo Momeni, Ph.D.,
Jordan Grafman, Ph.D.

Pages:362–369
Published Online:13 May 2020

https://doi.org/10.1176/appi.neuropsych.19100211

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Objective:The authors examined the effects of two common functional polymorphisms—brain-derived neurotrophic factor (BDNF) Val66Met and catechol-O-methyltransferase (COMT) Val158Met—on cognitive, neuropsychiatric, and motor symptoms and MRI findings in ...

Clinical and Research Reports

October 2020

Topography of Cholinergic Changes in Dementia With Lewy Bodies and Key Neural Network Hubs

Prabesh Kanel, Ph.D.,
Martijn L.T.M. Müller, Ph.D.,
Sygrid van der Zee, M.S.,
Carlos A. Sanchez-Catasus, Ph.D.,
Robert A. Koeppe, Ph.D.,
Kirk A. Frey, M.D., Ph.D.,
Nicolaas I. Bohnen, M.D., Ph.D.

Pages:370–375
Published Online:5 June 2020

https://doi.org/10.1176/appi.neuropsych.19070165

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Objectives:The authors investigated the topography of cholinergic vulnerability in patients with dementia with Lewy bodies (DLB) using positron emission tomography (PET) imaging with the vesicular acetylcholine transporter (VAChT) [¹⁸F]-...

October 2020

Bipolar Disorder Among Patients Diagnosed With Frontotemporal Dementia

Mario F. Mendez, M.D., Ph.D.,
Leila Parand, M.D.,
Golnoush Akhlaghipour, M.D.

Pages:376–384
Published Online:5 June 2020

https://doi.org/10.1176/appi.neuropsych.20010003

Abstract
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Objective:Previous studies have documented manic and hypomanic symptoms in behavioral variant frontotemporal dementia (bvFTD), suggesting a relationship between bipolar disorder and bvFTD.Methods:The investigators conducted a literature review as well as ...

October 2020

Psychiatric Morbidity and Its Prognosis in Posterior Reversible Encephalopathy Syndrome

Roxanne C. Keynejad, M.R.C.P., M.R.C.Psych., and
Anthony S. David, M.D., F.R.C.Psych.

Pages:385–388
Published Online:14 April 2020

https://doi.org/10.1176/appi.neuropsych.19080184

Abstract
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Posterior reversible encephalopathy syndrome (PRES) is a clinically and radiologically diagnosed disorder distinguished by subcortical vasogenic cerebral edema. To date, its presentation has been described through summarized neurological categories, such ...

Treatment in Behavioral Neurology & Neuropsychiatry

October 2020

Psychologically Informed Physical Therapy for Children and Adolescents With Functional Neurological Symptoms: The Wellness Approach

Nicola Gray, B.Phty.,
Blanche Savage, M.Psyc.(Clin.), Grad.Dip.,
Stephen Scher, Ph.D., J.D.,
Kasia Kozlowska, M.B.B.S., Ph.D.

Pages:389–395
Published Online:28 July 2020

https://doi.org/10.1176/appi.neuropsych.19120355

Abstract
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Children with functional neurological disorder (FND) present with motor and sensory neurological symptoms that impair health and physical functioning and that create an ongoing clinical burden for caregivers and hospitals worldwide. Treatment programs for ...

Introspections

October 2020

Of Ghost Grandparents and Missing Limbs

Miguel Restrepo-Martínez, M.D.

Pages:396–397
Published Online:13 May 2020

https://doi.org/10.1176/appi.neuropsych.20030044

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In Memoriam

October 2020

In Memoriam: Daniel I. Kaufer, M.D., F.A.N.P.A., F.A.A.N.

James R. Bateman, M.D., M.P.H.,
Bruce Miller, M.D.,
Adam Boxer, M.D.,
Howie Rosen, M.D., and
David B. Arciniegas, M.D.

Page:399
Published Online:29 October 2020

https://doi.org/10.1176/appi.neuropsych.3204obit

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Appreciation

October 2020

In Appreciation

Page:398
Published Online:29 October 2020

https://doi.org/10.1176/appi.neuropsych.320401

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