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Clinical and Research ReportsFull Access

Adjunctive Valproic Acid in Management-Refractory Hyperactive Delirium: A Case Series and Rationale

Published Online:24 Mar 2015https://doi.org/10.1176/appi.neuropsych.14080190

Abstract

Patients with delirium may fail to respond to standard therapies. Sixteen patients with management-refractory hyperactive delirium responded to adjunctive valproic acid, with complete resolution of hyperactive delirium in 13 cases. A rationale for using valproic acid in such circumstances is discussed.