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The Journal of Neuropsychiatry and Clinical Neurosciences

Volume 27, Issue 4

October 2015

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Windows to the Brain

October 2015

Neurobiology of Implicit and Explicit Bias: Implications for Clinicians

Kristina M. Reihl, Ph.D.,
Robin A. Hurley, M.D.,
Katherine H. Taber, Ph.D.

Pages:A6–253
Published Online:21 October 2015

https://doi.org/10.1176/appi.neuropsych.15080212

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Special Articles

October 2015

From Semantic to Social Deficits: Dysfunction of the Nondominant Posterior Perisylvian Area in Schizophrenia

Salvador M. Guinjoan, M.D., Ph.D.,
Delfina de Achával, Ph.D.,
Mirta F. Villarreal, Ph.D.,
Valeria Abusamra, Ph.D.,
Charles B. Nemeroff, M.D., Ph.D.

Pages:254–261
Published Online:12 June 2015

https://doi.org/10.1176/appi.neuropsych.14120377

Abstract
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Schizophrenia is characterized by profound deficits in social competence and functioning, independent from active psychotic symptoms at different stages of the disease. Social deficits in schizophrenia are clinically well characterized, but their ...

October 2015

Anxiety in Huntington’s Disease

Maria Dale, D.Clin.Psy., and
Erik van Duijn, M.D., Ph.D.

Pages:262–271
Published Online:24 March 2015

https://doi.org/10.1176/appi.neuropsych.14100265

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Anxiety is common in Huntington’s disease (HD), though it has been under-researched. The authors conducted a systematic review of anxiety in HD. The prevalence of anxiety in manifest HD ranged from 13% to 71%. No significant difference in anxiety between ...

Regular Articles

October 2015

Personality Change Due to Traumatic Brain Injury in Children and Adolescents: Neurocognitive Correlates

Jeffrey E. Max, M.B.B.Ch.,
Elisabeth A. Wilde, Ph.D.,
Erin D. Bigler, Ph.D.,
Gerri Hanten, Ph.D.,
Maureen Dennis, Ph.D.,
Russell J. Schachar, M.D.,
Ann E. Saunders, M.D.,
Linda Ewing-Cobbs, Ph.D.,
Sandra B. Chapman, Ph.D.,
Wesley K. Thompson, Ph.D.,
Tony T. Yang, M.D., Ph.D.,
Harvey S. Levin, Ph.D.

Pages:272–279
Published Online:17 July 2015

https://doi.org/10.1176/appi.neuropsych.15030073

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Personality change due to traumatic brain injury (PC) in children is an important psychiatric complication of injury and is a form of severe affective dysregulation. This study aimed to examine neurocognitive correlates of PC. The sample included 177 ...

October 2015

Preinjury Emotional-Behavioral Functioning of Children With Lingering Problems After Mild Traumatic Brain Injury

Robin L. Peterson, Ph.D.,
Amy K. Connery, Psy.D.,
David A. Baker, Psy.D.,
Michael W. Kirkwood, Ph.D.

Pages:280–286
Published Online:10 August 2015

https://doi.org/10.1176/appi.neuropsych.14120373

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This study aimed to characterize preinjury emotional-behavioral functioning in pediatric patients with lingering problems after mild traumatic brain injury (TBI). The clinical case series design included 278 patients 8–17 years old. Parents ...

October 2015

Persistent Postconcussive Symptoms Are Accompanied by Decreased Functional Brain Oxygenation

Ingo Helmich,
Rajeet S. Saluja, M.D.,
Hedda Lausberg, M.D., Ph.D.,
Mathias Kempe,
Philip Furley, Ph.D.,
Alisa Berger,
Jen-Kai Chen, Ph.D.,
Alain Ptito, Ph.D.

Pages:287–298
Published Online:24 March 2015

https://doi.org/10.1176/appi.neuropsych.14100276

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Diagnostic methods are considered a major concern in the determination of mild traumatic brain injury. The authors examined brain oxygenation patterns in subjects with severe and minor persistent postconcussive difficulties and a healthy control group ...

October 2015

Pathological Laughter and Crying and Psychiatric Comorbidity After Traumatic Brain Injury

Durga Roy, M.D.,
Una McCann, M.D.,
Dingfen Han, Ph.D.,
Vani Rao, M.D.

Pages:299–303
Published Online:10 August 2015

https://doi.org/10.1176/appi.neuropsych.15030045

Abstract
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There are limited data regarding the incidence of pathological laughter and crying (PLC) after traumatic brain injury (TBI). This study aimed to identify the occurrence of PLC in the first year after TBI and to determine whether there is a relationship ...

October 2015

Multigenerational Positive Family History of Psychiatric Disorders Is Associated With a Poor Prognosis in Bipolar Disorder

Robert M. Post, M.D.,
Lori Altshuler, M.D.,
Ralph Kupka, M.D.,
Susan L. McElroy, M.D.,
Mark A. Frye, M.D.,
Michael Rowe, Ph.D.,
Heinz Grunze, M.D.,
Trisha Suppes, M.D., Ph.D.,
Paul E. Keck, M.D.,
Gabriele S. Leverich, M.S.W.,
Willem A. Nolen, M.D.

Pages:304–310
Published Online:10 August 2015

https://doi.org/10.1176/appi.neuropsych.14080204

Abstract
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The authors assessed how family history loading affected the course of illness in patients from the United States. A total of 676 outpatients with bipolar disorder from the United States rated their illness and provided a parental and grandparental ...

October 2015

Retrospective Analysis of the Short-Term Safety of ECT in Patients With Neurological Comorbidities: A Guide for Pre-ECT Neurological Evaluations

Simon Ducharme, M.D., M.Sc.,
Evan D. Murray, M.D.,
Stephen J. Seiner, M.D.,
Haythum Tayeb, M.D.,
Benafew Legesse, M.D.,
Bruce H. Price, M.D.

Pages:311–321
Published Online:6 February 2015

https://doi.org/10.1176/appi.neuropsych.14080195

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Pre-ECT neurology consultations are often requested to determine the relative risk of the procedure in patients with neurological comorbidities, but there is limited data to guide clinicians. The authors performed a retrospective chart review of all ...

October 2015

APOE ε4 Genotype and the Risk for Subjective Cognitive Impairment in Elderly Persons

Janina Krell-Roesch, Ph.D.,
Bryan K. Woodruff, M.D.,
Jazmin I. Acosta, Ph.D.,
Dona E. Locke, Ph.D.,
Joseph G. Hentz, M.S.,
Cynthia M. Stonnington, M.D.,
Gorazd B. Stokin, M.D., Ph.D.,
Chelsea Nagle, B.S.,
Bernard F. Michel, M.D.,
Nathalie Sambuchi, Ph.D.,
Richard J. Caselli, M.D.,
Yonas E. Geda, M.D., M.Sc.

Pages:322–325
Published Online:24 March 2015

https://doi.org/10.1176/appi.neuropsych.14100268

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The authors compared the risk for subjective cognitive impairment (SCI) between carriers of the apolipoprotein E ε4 (APOE ε4) allele (cases) and APOE ε4 noncarriers (controls). SCI was assessed by a validated self-reported questionnaire. The authors used ...

October 2015

Antipsychotic Use in a Diverse Population With Dementia: A Retrospective Review of the National Alzheimer’s Coordinating Center Database

Glen L. Xiong, M.D.,
Teresa Filshtein, M.S.,
Laurel A. Beckett, Ph.D.,
Ladson Hinton, M.D.

Pages:326–332
Published Online:21 October 2015

https://doi.org/10.1176/appi.neuropsych.15010020

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A cross-sectional analysis examined medication records in the National Alzheimer’s Coordinating Center Database for community-dwelling patients with dementia who visited an Alzheimer’s Disease Center between 2008 and 2014. Hispanic participants had a 1.62-...

October 2015

Natural History of Poststroke Apathy During Acute Rehabilitation

Juliana M. Kennedy, B.S.,
Dora A. Granato, M.S., C.C.C.-S.L.P.,
Andrew M. Goldfine, M.D.

Pages:333–338
Published Online:17 July 2015

https://doi.org/10.1176/appi.neuropsych.15010001

Abstract
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To better understand the natural history of poststroke apathy, the authors tested 96 patients undergoing acute rehabilitation for stroke using the Apathy Inventory. A total of 28% of patients had apathy. Their Apathy Inventory scores improved a mean of 1 ...

October 2015

Social Anxiety Level in Adult Patients With Epilepsy and Their First-Degree Cohabiting Relatives

Ebru Altintas, M.D.,
V. Deniz Yerdelen, M.D., Proff.,
Nilgün Taskintuna, M.D., Proff.

Pages:339–344
Published Online:17 July 2015

https://doi.org/10.1176/appi.neuropsych.15030061

Abstract
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Epilepsy affects not only the patient but also the patient’s cohabiting relatives, to various degrees. This study investigated state and trait anxiety, depression, and social fear and avoidance levels in 48 adult patients with epilepsy and 48 family ...

October 2015

Neural Correlates of Intolerance of Uncertainty in Clinical Disorders

Mirjam Wever, M.Sc.
Paul Smeets, Ph.D.
Lot Sternheim, Ph.D.

Pages:345–353
Published Online:17 July 2015

https://doi.org/10.1176/appi.neuropsych.14120387

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Intolerance of uncertainty is a key contributor to anxiety-related disorders. Recent studies highlight its importance in other clinical disorders. The link between its clinical presentation and the underlying neural correlates remains unclear. This review ...

October 2015

Research Trends in the Neuropsychiatry Literature Since the New Millennium

Harry Srirathan, B.Med.Sc., and
Andrea E. Cavanna, M.D., Ph.D., F.R.C.P.

Pages:354–361
Published Online:10 August 2015

https://doi.org/10.1176/appi.neuropsych.15010024

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The authors examined current research trends in neuropsychiatry by analyzing original research studies published since the new millennium. A total of 14,587 articles published between 2000 and 2013 were systematically screened from 10 neuropsychiatry ...

Clinical and Research Reports

October 2015

The Effect of Repeated Ketamine Infusion Over Facial Emotion Recognition in Treatment-Resistant Depression: A Preliminary Report

Paulo R. Shiroma, M.D.
C. Sophia Albott, M.D.
Brian Johns, M.D.
Paul Thuras, Ph.D.
Joseph Wels, M.D.
Kelvin O. Lim, M.D.

Pages:362–364
Published Online:6 February 2015

https://doi.org/10.1176/appi.neuropsych.14100243

Abstract
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In contrast to improvement in emotion recognition bias by traditional antidepressants, the authors report preliminary findings that changes in facial emotion recognition are not associated with response of depressive symptoms after repeated ketamine ...

October 2015

Adjunctive Valproic Acid in Management-Refractory Hyperactive Delirium: A Case Series and Rationale

Yelizaveta Sher, M.D.,
Anne Catherine Miller, M.D.,
Sermsak Lolak, M.D.,
Andrea Ament, M.D.,
José R. Maldonado, M.D.

Pages:365–370
Published Online:24 March 2015

https://doi.org/10.1176/appi.neuropsych.14080190

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Patients with delirium may fail to respond to standard therapies. Sixteen patients with management-refractory hyperactive delirium responded to adjunctive valproic acid, with complete resolution of hyperactive delirium in 13 cases. A rationale for using ...

In Appreciation

October 2015

In Appreciation

Pages:371–372
Published Online:21 October 2015

https://doi.org/10.1176/appi.neuropsych.270401

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Correction

October 2015

Page:372
Published Online:21 October 2015

https://doi.org/10.1176/appi.neuropsych.274correction

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