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The Journal of Neuropsychiatry and Clinical Neurosciences

Volume 29, Issue 1

January 2017

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Windows to the Brain

January 2017

Chronic Alcohol Use and Sleep Homeostasis: Risk Factors and Neuroimaging of Recovery

Sarah L. Martindale, Ph.D.,
Robin A. Hurley, M.D.,
Katherine H. Taber, Ph.D.

Pages:A6–5
Published Online:1 February 2017

https://doi.org/10.1176/appi.neuropsych.16110307

First Page
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Regular Articles

January 2017

Cognitive Reserve as a Modifier of Clinical Expression in Chronic Traumatic Encephalopathy: A Preliminary Examination

Michael L. Alosco, Ph.D.,
Jesse Mez, M.D., M.S.,
Neil W. Kowall, M.D.,
Thor D. Stein, M.D., Ph.D.,
Lee E. Goldstein, M.D., Ph.D.,
Robert C. Cantu, M.D.,
Douglas I. Katz, M.D.,
Todd M. Solomon, Ph.D.,
Patrick T. Kiernan, B.A.,
Lauren Murphy, B.A.,
Bobak Abdolmohammadi, B.A.,
Daniel Daneshvar, M.D., Ph.D.,
Philip H. Montenigro, B.S.,
Christopher J. Nowinski, B.A.,
Robert A. Stern, Ph.D.,
Ann C. McKee, M.D.

Pages:6–12
Published Online:19 August 2016

https://doi.org/10.1176/appi.neuropsych.16030043

Abstract
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This study conducted a preliminary examination on cognitive reserve (CR) as a modifier of symptom expression in subjects with autopsy-confirmed chronic traumatic encephalopathy (CTE). The sample included 25 former professional football players ...

January 2017

Cross-Ethnic Differences in the Severity of Neuropsychiatric Symptoms in Persons With Mild Cognitive Impairment and Alzheimer's Disease

Ricardo Salazar, M.D.,
Alok Kumar Dwivedi, Ph.D.,
Donald R. Royall, M.D.

Pages:13–21
Published Online:15 July 2016

https://doi.org/10.1176/appi.neuropsych.15120423

Abstract
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In this cross-sectional study, we examined the neuropsychiatric profile of mild cognitive impairment (MCI) and Alzheimer's disease (AD) using the Neuropsychiatric Inventory Questionnaire (NPI-Q). Data were available on 875 controls, 339 MCI cases, and 975 ...

January 2017

Cognitive Effects of Rasagiline in Mild-to-Moderate Stage Parkinson's Disease Without Dementia

Laura L. Frakey, Ph.D.,
Joseph H. Friedman, M.D.

Pages:22–25
Published Online:10 November 2016

https://doi.org/10.1176/appi.neuropsych.15050118

Abstract
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The authors studied the effects of rasagiline on cognition in a sample of 50 nondemented patients with mild to moderate Parkinson’s disease (PD) using a double-blind, placebo controlled design. Cognition and motor symptoms were assessed at baseline and ...

January 2017

Frontotemporal Lobar Degeneration-Modified Clinical Dementia Rating (FTLD-CDR) Scale and Frontotemporal Dementia Rating Scale (FRS) Correlation With Regional Brain Perfusion in a Series of FTLD Patients

Pantelis Maiovis, M.D.,
Panagiotis Ioannidis, M.D., Ph.D.,
Georgios Gerasimou, M.D., Ph.D.,
Anna Gotzamani-Psarrakou, M.D., Ph.D.,
Dimitrios Karacostas, M.D., Ph.D.

Pages:26–30
Published Online:15 July 2016

https://doi.org/10.1176/appi.neuropsych.16020034

Abstract
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Severity assessment scales for frontotemporal lobar degeneration (FTLD) have been recently introduced. In the present study, the authors examined whether the FTLD-modified Clinical Dementia Rating (FTLD-CDR) scale and the Frontotemporal Dementia Rating ...

January 2017

Spanish Validation of the Problem Behaviors Assessment–Short (PBA-s) for Huntington’s Disease

Jesús M. Ruiz-Idiago, M.D.,
Misericordia Floriach, M.D.,
Cèlia Mareca, Bs.C.,
Raymond Salvador, Ph.D.,
José Luis López-Sendón, M.D.,
Verónica Mañanés, Bs.C.,
Esther Cubo, M.D., Ph.D.,
Natividad Mariscal, CNS,
Esteban Muñoz, M.D.,
Pilar Santacruz, Bs.C.,
María F. Noguera, M.D.,
Laura Vivancos, Bs.C.,
Pedro Roy, M.D.,
Edith Pomarol-Clotet, Ph.D., M.D.,
Salvador Sarró, M.D.,
on behalf of the Spanish Huntington Disease Network

Pages:31–38
Published Online:15 July 2016

https://doi.org/10.1176/appi.neuropsych.16020025

Abstract
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A prospective, observational multicenter study was carried out assessing neuropsychiatric symptoms in a sample of 117 subjects in order to validate the Spanish version of the Problem Behaviors Assessment-Short (PBA-s). The psychometric properties of this ...

January 2017

Microbiome-Gut-Brain Axis: Probiotics and Their Association With Depression

M. Soledad Cepeda, M.D., Ph.D.,
Eva G. Katz, Ph.D., M.P.H., R.D.,
Clair Blacketer, M.P.H.

Pages:39–44
Published Online:19 August 2016

https://doi.org/10.1176/appi.neuropsych.15120410

Abstract
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To assess the association of probiotics with depression, a large population-based cross-sectional study was conducted. National Health and Nutrition Examination Survey adult participants from 2005 through 2012 were included. Exposure was defined as having ...

January 2017

The Prevalence of Bipolar Disorders and Association With Quality of Life in a Cohort of Patients With Multiple Sclerosis

Adalia H. Jun-O’Connell, M.D.,
Ankur Butala, M.D.,
Idanis Berrios Morales, M.D.,
Nils Henninger, M.D.,
Kristina M. Deligiannidis, M.D.,
Nancy Byatt, D.O., M.S., M.B.A., FAPM.,
Carolina Ionete, M.D., Ph.D.

Pages:45–51
Published Online:19 August 2016

https://doi.org/10.1176/appi.neuropsych.15120403

Abstract
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Clinical observations of mood instability in multiple sclerosis (MS) have led to the hypothesis that bipolar disorder (BD) may be more prevalent in persons with MS than in the general population. This cross-sectional study assesses the prevalence of BD ...

January 2017

Mood Symptoms and Restless Legs Syndrome Without Periodic Limb Movements During Sleep: Is it a Clinical Subtype?

Hochang B. Lee, M.D.,
Mei Ling Song, R.N., M.S.N.,
Brian B. Koo, M.D.,
Yong Won Cho, M.D., Ph.D.

Pages:52–59
Published Online:15 July 2016

https://doi.org/10.1176/appi.neuropsych.15090228

Abstract
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Frequently co-occurring restless legs syndrome (RLS) and periodic limb movements during sleep (PLMS) are postulated to share common pathophysiology. The authors compared clinical characteristics and polysomnography (PSG) parameters among 155 idiopathic, ...

Clinical and Research Reports

January 2017

Cortical Thickness and Anxiety Symptoms Among Cognitively Normal Elderly Persons: The Mayo Clinic Study of Aging

Anna Pink, M.D.,
Scott A. Przybelski, B.S.,
Janina Krell-Roesch, Ph.D.,
Gorazd B. Stokin, M.D., Ph.D.,
Rosebud O. Roberts, M.B. Ch.B., M.S.,
Michelle M. Mielke, Ph.D.,
Kathleen A. Spangehl, M.A.,
David S. Knopman, M.D.,
Clifford R. Jack, M.D.,
Ronald C. Petersen, M.D., Ph.D.,
Yonas E. Geda, M.D., M.Sc.

Pages:60–66
Published Online:31 August 2016

https://doi.org/10.1176/appi.neuropsych.15100378

Abstract
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The authors conducted a cross-sectional study to investigate the association between anxiety symptoms and cortical thickness, as well as amygdalar volume. A total of 1,505 cognitively normal participants, aged ≥70 years, were recruited from the Mayo ...

January 2017

Depression and Anxiety Following Aneurysmal Subarachnoid Hemorrhage Are Associated With Higher Six-Month Unemployment Rates

Altaib Al Yassin, M.D., M.S.,
Bichun Ouyang, Ph.D.,
Richard Temes, M.D.

Pages:67–69
Published Online:15 July 2016

https://doi.org/10.1176/appi.neuropsych.15070171

Abstract
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Although survival has dramatically improved following aneurysmal subarachnoid hemorrhage (aSAH), the reasons for persistent high rates of unemployment in this population remain unknown. Retrospective review for medical records of patients with aSAH ...

January 2017

Effects of Transcranial Magnetic Stimulation on the Hypothalamic-Pituitary Axis in Depression: Results of a Pilot Study

Vincent Meille, M.D.,
Bruno Verges, M.D., Ph.D.,
Laurence Lalanne, M.D., Ph.D.,
Lysiane Jonval, M.Sc.,
Laurence Duvillard, M.D., Ph.D.,
Jean-Christophe Chavet-Gelinier, M.D., Ph.D.,
Bernard Bonin, M.D., Ph.D.,
Benoit Trojak, M.D., Ph.D.

Pages:70–73
Published Online:19 August 2016

https://doi.org/10.1176/appi.neuropsych.16010013

Abstract
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Some studies have reported that repetitive transcranial magnetic stimulation (rTMS) applied to the dorsolateral prefrontal cortex (DLPFC) is able to induce changes in the hypothalamic-pituitary axis in subjects with major depression. The causes of these ...

January 2017

Onconeural Antibodies in Acute Psychiatric Inpatient Care

Sverre Georg Sæther, M.D.,
Morten Schou, M.D.,
Winfried Stoecker, M.D., Ph.D.,
Bianca Teegen, Ph.D.,
Kathrin Borowski,
Arne Vaaler, M.D., Ph.D.,
Daniel Kondziella, M.D., Ph.D.,
Solveig Klæbo Reitan, M.D., Ph.D.

Pages:74–76
Published Online:31 August 2016

https://doi.org/10.1176/appi.neuropsych.16050110

Abstract
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Paraneoplastic neurological disorders associated with onconeural antibodies often appear with neuropsychiatric symptoms. To study the prevalence of onconeural antibodies in patients admitted to acute psychiatric inpatient care, the serum of 585 such ...

Case Reports

January 2017

Refractory OCD Due to Thalamic Infarct With Response to Dronabinol

Joseph J. Cooper, M.D.,
Jon Grant, J.D., M.D., M.P.H.

Pages:77–78
Published Online:19 August 2016

https://doi.org/10.1176/appi.neuropsych.16030053

Abstract
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Structural brain lesions can be a rare cause of refractory psychiatric symptoms. The analysis of such cases may lead to insights into psychiatric neurobiology. Here we present a case of a dronabinol-responsive obsessive-compulsive syndrome after thalamic ...

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