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The Journal of Neuropsychiatry and Clinical Neurosciences

Volume 31, Issue 4

October 2019

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Windows to the Brain

October 2019

Positron Emission Tomography: Updates on Imaging of Addiction

Kiran Kumar Solingapuram Sai, Ph.D.,
Robin A. Hurley, M.D.,
Meghana Dodda,
Katherine H. Taber, Ph.D.

Pages:A6–288
Published Online:15 October 2019

https://doi.org/10.1176/appi.neuropsych.19080169

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Special Articles

October 2019

Neuroprotective Benefits of Antidepressants in Multiple Sclerosis: Are We Missing the Mark?

Lisa B. Grech, Ph.D.,
Ernest Butler, M.D., Ph.D.,
Stephen Stuckey, M.D.,
Robert Hester, Ph.D.

Pages:289–297
Published Online:3 April 2019

https://doi.org/10.1176/appi.neuropsych.18070164

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The potential of antidepressant medication to have a neuroprotective effect for people with multiple sclerosis (MS) has received increased interest in recent years. The possibility of antidepressants, particularly fluoxetine, for potential repurposing to ...

Regular Articles

October 2019

Association of COMT Val¹⁵⁸Met Polymorphism With Delirium Risk and Outcomes After Traumatic Brain Injury

Deividas Nekrosius,
Migle Kaminskaite, M.D.,
Ramunas Jokubka, Ph.D.,
Aiste Pranckeviciene, Ph.D.,
Karolis Lideikis,
Arimantas Tamasauskas, M.D., Ph.D.,
Adomas Bunevicius, M.D., Ph.D.

Pages:298–305
Published Online:3 May 2019

https://doi.org/10.1176/appi.neuropsych.18080195

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Objective:The authors investigated the association of the catechol-o-methyltransferase (COMT) gene Val¹⁵⁸Met polymorphism with delirium risk and functional and cognitive outcomes among patients with complicated mild to moderate traumatic brain injury (TBI)...

October 2019

Low-Frequency Right Repetitive Transcranial Magnetic Stimulation for the Treatment of Depression After Traumatic Brain Injury: A Randomized Sham-Controlled Pilot Study

Vani Rao, M.D.,
Kathleen Bechtold, Ph.D., Ph.D.,
Una McCann, M.D.,
Durga Roy, M.D.,
Matthew Peters, M.D.,
Sandeep Vaishnavi, M.D., Ph.D.,
David Yousem, M.D., M.B.A.,
Susumu Mori, Ph.D.,
Haijuan Yan, Ph.D.,
Jeannie Leoutsakos, Ph.D.,
Michael Tibbs, Ph.D.,
Irving Reti, M.B.B.S.

Pages:306–318
Published Online:25 April 2019

https://doi.org/10.1176/appi.neuropsych.17110338

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Objective:Major depression is the most common psychiatric sequela of traumatic brain injury (TBI), but effective treatment continues to be a challenge, with few studies providing guidance.Methods:In a pilot study, the authors evaluated the effect size of ...

October 2019

Treating Alcohol Use Disorder in U.S. Veterans: The Role of Traumatic Brain Injury

Ricardo E. Jorge, M.D.,
Ruosha Li, Ph.D.,
Xiangyu Liu, B.S.,
Jill K. McGavin, Ph.D.,
Daryl I. Shorter, M.D.,
Laura Acion, Ph.D.,
Stephan Arndt, Ph.D.

Pages:319–327
Published Online:23 May 2019

https://doi.org/10.1176/appi.neuropsych.18110250

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Objective:The authors examined the efficacy of valproate to reduce relapse to heavy drinking among veterans with alcohol use disorder (AUD) and neuropsychiatric comorbidities and whether antecedent traumatic brain injury (TBI) or posttraumatic stress ...

October 2019

Anger and Depression in Middle-Aged Men: Implications for a Clinical Diagnosis of Chronic Traumatic Encephalopathy

Grant L. Iverson, Ph.D.,
Douglas P. Terry, Ph.D.,
Matthew Luz, B.S.,
Ross Zafonte, D.O.,
Paul McCrory, M.B.B.S., Ph.D.,
Gary S. Solomon, Ph.D.,
Andrew J. Gardner, Ph.D.

Pages:328–336
Published Online:25 April 2019

https://doi.org/10.1176/appi.neuropsych.18110280

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Objective:In recent years, it has been proposed that problems with anger control and depression define clinical features of chronic traumatic encephalopathy (CTE). The authors examined anger problems and depression in middle-aged men from the general ...

October 2019

Cognitive Impairment and Predicting Response to Treatment in an Intensive Clinical Program for Post-9/11 Veterans With Posttraumatic Stress Disorder

Kaloyan S. Tanev, M.D.,
Lydia E. Federico, A.B.,
Douglas P. Terry, Ph.D.,
Erika L. Clark, Ph.D.,
Grant L. Iverson, Ph.D.

Pages:337–345
Published Online:25 April 2019

https://doi.org/10.1176/appi.neuropsych.18090208

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Objective:This study examined whether objectively measured pretreatment cognitive impairment predicted worse response to treatment for posttraumatic stress disorder. Participants were 113 veterans and active duty service members who participated in a new ...

October 2019

Ages at Onset of Anxiety and Depressive Disorders in Parkinson’s Disease

Andreea L. Seritan, M.D.,
Christopher Rienas, M.D.,
Tammy Duong, M.D.,
Kevin Delucchi, Ph.D.,
Jill L. Ostrem, M.D.

Pages:346–352
Published Online:23 May 2019

https://doi.org/10.1176/appi.neuropsych.18090201

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Objective:Parkinson’s disease (PD) is a quintessential neuropsychiatric condition in which anxiety and depressive symptoms are common and may precede motor manifestations. The authors explored the ages at onset of anxiety and depressive disorders among ...

October 2019

A Continuous Clustering Algorithm for Detection of Local Sleep in Humans

Mircea I. Chelaru, Ph.D., and
Jeremy D. Slater, M.D.

Pages:353–360
Published Online:3 May 2019

https://doi.org/10.1176/appi.neuropsych.17090186

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Objective:Research in animal models has shown that many EEG sleep features reflect local conditions, which is a consequence of relative inactivity of neuronal clusters. In humans, the authors previously reported that focal sleep patterns appear on the ...

October 2019

Hiding in Plain Sight: Functional Neurological Disorders in the News

Stoyan Popkirov, M.D.,
Timothy R. Nicholson, M.D., Ph.D.,
Bastiaan R. Bloem, M.D., Ph.D.,
Hannah R. Cock, M.D.,
Christopher P. Derry, Ph.D.,
Roderick Duncan, M.D., Ph.D.,
Barbara A. Dworetzky, M.D.,
Mark J. Edwards, Ph.D.,
Alberto J. Espay, M.D.,
Mark Hallett, M.D.,
Anthony E. Lang, M.D.,
John Paul Leach, M.D.,
Alexander Lehn, M.D.,
Aileen McGonigal, M.D., Ph.D.,
Francesca Morgante, M.D.,
David L. Perez, M.D., M.M.Sc.,
Markus Reuber, Ph.D.,
Mark P. Richardson, Ph.D.,
Philip Smith, M.D.,
Maria Stamelou, M.D.,
Marina A. J. Tijssen, M.D.,
Michele Tinazzi, M.D.,
Alan J. Carson, M.D.,
Jon Stone, Ph.D.

Pages:361–367
Published Online:23 May 2019

https://doi.org/10.1176/appi.neuropsych.19010025

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Objective:Functional movement and seizure disorders are still widely misunderstood and receive little public and academic attention. This is in stark contrast to their high prevalence and levels of associated disability. In an exploratory observational ...

October 2019

Association of Working Memory With Distributed Executive Control Networks in Schizophrenia

Korey P. Wylie, M.D.,
Josette G. Harris, Ph.D.,
Debashis Ghosh, Ph.D.,
Ann Olincy, M.D.,
Jason R. Tregellas, Ph.D.

Pages:368–377
Published Online:23 May 2019

https://doi.org/10.1176/appi.neuropsych.18060131

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Objective:Working memory impairments represent a core cognitive deficit in schizophrenia, predictive of patients’ daily functioning, and one that is unaffected by current treatments. To address this, working memory is included in the MATRICS Consensus ...

Clinical and Research Reports

October 2019

Impaired Empathy Versus General Hypoemotionality in Frontotemporal Dementia

Mario F. Mendez, M.D., Ph.D.,
Andrew R. Carr,
Elvira E. Jimenez, M.P.H.,
Brandalyn C. Riedel, M.S.G.,
Paul M. Thompson, Ph.D.

Pages:378–385
Published Online:3 May 2019

https://doi.org/10.1176/appi.neuropsych.18090202

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Objective:Impaired empathy is a diagnostic feature of behavioral variant frontotemporal dementia (bvFTD), but it is not clear whether it is caused by a primary impairment in empathy or by general emotional blunting.Methods:Patients with bvFTD who met ...

Treatment in Behavioral Neurology & Neuropsychiatry

October 2019

Management of Insomnia and Anxiety in Myasthenia Gravis

Holly Jordan, M.D., and
Natalia Ortiz, M.D.

Pages:386–391
Published Online:10 June 2019

https://doi.org/10.1176/appi.neuropsych.18120383

Abstract
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Myasthenia gravis is a neuroimmunological disorder leading to skeletal muscle weakness. Common symptoms of the disease, such as anxiety, depression, and insomnia, can cause significant distress in patients. Unfortunately, selecting an appropriate ...

Case Report

October 2019

An Opioid-Related Amnestic Syndrome With Persistent Effects on Hippocampal Structure and Function

P. Monroe Butler, M.D., Ph.D.,
Jed A. Barash, M.D.,
Kaitlin B. Casaletto, Ph.D.,
Devyn L. Cotter, M.Sc.,
Renaud La Joie, Ph.D.,
Michael D. Geschwind, M.D., Ph.D.,
Howie J. Rosen, M.D.,
Joel H. Kramer, Psy.D.,
Bruce L. Miller, M.D.

Pages:392–396
Published Online:10 June 2019

https://doi.org/10.1176/appi.neuropsych.19010017

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Icons in Neuropsychiatry

October 2019

Wilder Penfield and the Architecture of Collaboration

Barbara Schildkrout, M.D.,
Lindsey MacGillivray, M.D., Ph.D.,
Margo Lauterbach, M.D.

Pages:397–398
Published Online:15 October 2019

https://doi.org/10.1176/appi.neuropsych.19020041

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Letters

October 2019

Phenomenology and Management of Encephalitis

Stanley N. Caroff, M.D.

Page:399
Published Online:15 October 2019

https://doi.org/10.1176/appi.neuropsych.18120392

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October 2019

Risk of Neuroleptic Malignant Syndrome in Encephalitides: Response to Caroff

Rani A. Sarkis, M.D., M.Sc.

Page:400
Published Online:15 October 2019

https://doi.org/10.1176/appi.neuropsych.18120392r

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Departments

October 2019

In Appreciation

Page:401
Published Online:15 October 2019

https://doi.org/10.1176/appi.neuropsych.310401

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