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Previous Issue Next Issue

The Journal of Neuropsychiatry and Clinical Neurosciences

Volume 17, Issue 4

November 2005

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Windows to the Brain

November 2005

Blood Flow Imaging of the Brain: 50 Years Experience

Katherine H. Taber, Ph.D.,
Kevin J. Black, M.D., and
Robin A. Hurley, M.D.

Pages:441–446
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.441

First Page
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Special Article

November 2005

Review of Pseudobulbar Affect Including a Novel and Potential Therapy

Randolph Schiffer, M.D., and
Laura E. Pope, Ph.D.

Pages:447–454
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.447

Abstract
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Pseudobulbar affect (PBA) is an affective disinhibition syndrome associated with various neuropathologies, which is characterized by involuntary and inappropriate outbursts of laughter and/or crying. The PBA syndrome can be socially and occupationally ...

November 2005

A Four-Step Approach for Developing Diagnostic Tests in Psychiatry: EEG in ADHD as a Test Case

Nash Boutros, M.D.,
Liana Fraenkel, M.D., and
Alan Feingold, Ph.D.

Pages:455–464
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.455

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A four-step approach for developing diagnostic tests in psychiatry is proposed. The approach was applied to a promising finding (increased electroencephalogram [EEG] Theta in attention deficit hyperactivity disorder [ADHD]). A meta-analysis for the effect ...

Regular Article

November 2005

Association of COMT Val158Met Genotype With Executive Functioning Following Traumatic Brain Injury

Robert H. Lipsky, Ph.D.,
Molly B. Sparling, B.A.,
Laurie M. Ryan, Ph.D.,
Ke Xu, M.D., Ph.D.,
Andres M. Salazar, M.D.,
David Goldman, M.D., and
Deborah L. Warden, M.D.

Pages:465–471
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.465

Abstract
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Catechol-O-methyltransferase (COMT) is thought to functionally modulate dopamine neurons, thus likely influencing frontal-executive functioning. High enzyme activity (COMT Val) and low enzyme activity (COMT Met) are functional polymorphisms resulting from ...

November 2005

Neurological Soft Signs as Predictors of Treatment Response to Selective Serotonin Reuptake Inhibitors in Obsessive-Compulsive Disorder

Eric Hollander, M.D.,
Alicia Kaplan, M.D.,
James Schmeidler, Ph.D.,
Haichen Yang, M.D.,
David Li, Ph.D.,
Lorrin M. Koran, M.D., and
Luigi M. Barbato, M.D.

Pages:472–477
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.472

Abstract
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Neurological soft-sign abnormalities have been implicated in obsessive-compulsive disorder (OCD). This first comprehensive data analysis evaluated the association between baseline neurological soft signs and treatment response in 117 OCD patients treated ...

November 2005

Long-Term Outcome of Neurosurgery for the Treatment of Resistant Depression

Perminder S. Sachdev, MBBS, M.D., Ph.D., FRANZCP, and
Jagdeep Sachdev, FRANZCP

Pages:478–485
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.478

Abstract
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Between 1973 and 1995, a total of 76 patients were treated with bilateral stereotactic, orbitomedial lesions for resistant severe depression at the Neuropsychiatric Institute, Sydney, Australia. On follow up after a mean 14.4 years, 24 (31.6%) subjects ...

November 2005

Treatment of Acute Ischemic Stroke: Does It Impact Neuropsychiatric Outcome?

C. Alan Anderson, M.D.,
David B. Arciniegas, M.D., and
Christopher M. Filley, M.D.

Pages:486–488
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.486

Abstract
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Stroke is a leading cause of disability globally. Although neuropsychiatric symptoms are produced by stroke and adversely effect stroke outcome, it is unclear whether neuropsychiatric outcome can be improved by acute stroke treatment. The authors reviewed ...

November 2005

Psychiatric Manifestations of Creutzfeldt-Jakob Disease: A 25-Year Analysis

Christopher A. Wall, M.D.,
Teresa A. Rummans, M.D.,
Allen J. Aksamit, M.D.,
Lois E. Krahn, M.D., and
V. Shane Pankratz, Ph.D.

Pages:489–495
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.489

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This study characterizes the type and timing of psychiatric manifestations in sporadic Creutzfeldt-Jakob disease (sCJD). Historically, sCJD has been characterized by prominent neurological symptoms, while the variant form (vCJD) is described as primarily ...

November 2005

Depression and Stages of Huntington’s Disease

Jane S. Paulsen, Ph.D.,
Carissa Nehl, B.S.,
Karin Ferneyhough Hoth, M.A.,
Jason E. Kanz, M.S.,
Michelle Benjamin, B.S.,
Rachel Conybeare, B.S.,
Bradley McDowell, Ph.D., and
Beth Turner, B.S.The Huntington Study Group

Pages:496–502
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.496

Abstract
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Individuals with manifest Huntington’s disease (HD) were interviewed with regard to the presence, frequency, and severity of depression symptoms to better characterize depressed mood across the disease course in HD. Rates of depression were more than ...

November 2005

Postmortem Locus Coeruleus Neuron Count in Three American Veterans With Probable or Possible War-Related PTSD

H. Stefan Bracha, M.D.,
Edgar Garcia-Rill, Ph.D.,
Robert E. Mrak, M.D., Ph.D., and
Robert Skinner, Ph.D.

Pages:503–509
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.503

Abstract
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The authors investigated whether war-related posttraumatic stress disorder (WR-PTSD) is associated with a postmortem change in neuronal counts in the locus coeruleus (LC) since enhanced central nervous system (CNS) noradrenergic postsynaptic ...

November 2005

Relative Sparing of Executive Functions in the Early Phase of Schizophrenia

E. Cem Atbasoglu, M.D.,
Halise D. Ozguven, M.D.,
Meram Can Saka, M.D., and
Senay Olmez, M.A.

Pages:510–516
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.510

Abstract
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Findings about the impairment of executive functions in schizophrenia are not conclusive. The authors hypothesized that the severity of the impairments in the abilities that comprise EF might be different. Forty patients were assessed with a comprehensive ...

November 2005

Behavioral and Electrophysiological Indices of Temporal Processing Dysfunction in Schizophrenia

Deana B. Davalos, Ph.D.,
Michael A. Kisley, Ph.D., and
Robert Freedman, M.D.

Pages:517–525
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.517

Abstract
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Timing deficits in schizophrenia have been noted in several behavioral studies. However, the involvement of mediating factors, such as inattention, has not been ruled out as contributing to these effects. Mismatch negativity (MMN), an electrophysiological ...

November 2005

High–Resolution Brain SPECT Imaging and Eye Movement Desensitization and Reprocessing in Police Officers With PTSD

Karen Lansing, M.F.T, B.C.E.T.S.,
Daniel G. Amen, M.D.,
Chris Hanks, Ph.D., and
Lisa Rudy, B.A.

Pages:526–532
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.526

Abstract
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Eye movement desensitization and reprocessing (EMDR) has been shown to be an effective treatment for posttraumatic stress disorder (PTSD). In this study, the authors evaluated the effectiveness and physiological effects of EMDR in police officers involved ...

November 2005

The Clock Drawing Test: Diagnostic, Functional, and Neuroimaging Correlates in Older Medically Ill Adults

Julia B. Samton, M.D.,
Stephen J. Ferrando, M.D.,
Pina Sanelli, M.D.,
Sassan Karimi, M.D.,
Valentine Raiteri, M.D., and
John W. Barnhill, M.D.

Pages:533–540
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.533

Abstract
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This study evaluated the clock drawing test (CDT), a screening test sensitive to executive function, in 70 elderly psychiatric consultation patients. The CDT was compared to the Mini-Mental Status Examination (MMSE) on associations with psychiatric ...

Clinical and Research Reports

November 2005

Neuropsychiatric Associations of Apolipoprotein E Alleles in Subjects With Combat-Related Posttraumatic Stress Disorder

Thomas Freeman, M.D.,
Vincent Roca, Ph.D.,
Fred Guggenheim, M.D.,
Tim Kimbrell, M.D., and
W.S.T. Griffin, Ph.D.

Pages:541–543
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.541

Abstract
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Previous studies have reported associations between apolipoprotein E (APOE) genotype, cognitive function, and psychopathology in psychiatric populations. The authors investigated the associations between APOE allele status, memory function, and ...

November 2005

Obsessive-Compulsive Spectrum Disorders in Rheumatic Fever Patients

Marcos T. Mercadante, M.D., Ph.D.,
Juliana B. Diniz, M.D.,
Ana G. Hounie, M.D., Ph.D.,
Ygor Ferrão, M.D., M.Sc.,
Pedro Alvarenga, M.D.,
Sergio Brotto, M.D., and
Euripedes C. Miguel, M.D., Ph.D.

Pages:544–547
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.544

Abstract
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Based on five cases of obsessive-compulsive spectrum disorders in rheumatic fever patients, the authors discuss the range of psychiatric disorders associated with poststreptococcal autoimmune reactions and its implications for immunology/CNS interaction.

November 2005

Cranial Electrotherapy Stimulation Reduces Aggression in a Violent Retarded Population: A Preliminary Report

Allen Childs, M.D., F.A.P.A.

Pages:548–551
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.548

Abstract
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Nine aggressive, retarded patients refractory to conventional care at a maximum security hospital were given a 3-month course of cranial electrotherapy stimulation. Aggressive episodes declined 59% from baseline; seclusions were down 72%; restraints were ...

November 2005

Emergent Complications Following Donepezil Switchover to Galantamine in Three Cases of Dementia With Lewy Bodies

Nadeem H. Bhanji, BSc(Pharm), M.D., F.R.C.P.(C), and
Serge Gauthier, M.D., F.R.C.P.(C)

Pages:552–555
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.552

Abstract
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Delayed disease progression and symptomatic improvement occur with cholinesterase inhibitors (ChEIs) in dementia with Lewy bodies (DLB). In this study, complications (insomnia, dyskinesias, agitation, and delirium) occurred in three patients switched from ...

Book Reviews

November 2005

The Neurobiology of Mental Illness

Reviewed by Anjan Chatterjee, M.D. M.P.H.

Pages:556–557
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.556

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Letter

November 2005

Effect of Aripiprazole for a Patient With Psychotic Symptoms and Parkinsonism Associated With Delayed-Sequelae of Carbon Monoxide Intoxication

Chi-Un Pae, M.D.,
Tae-Suk Kim, M.D.,
Chul Lee, M.D., and
In-Ho Paik, M.D., Department of Psychiatry, Kangnam St. Mary’s Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea; Clinical Trials Program, Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC

Page:558
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.558

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November 2005

“Seeing Catatonia”

Jeff Seaman, M.D., M.S., Associate Professor of Psychiatry, Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK

Pages:558-a–559
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.558-a

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November 2005

Worsening of Borderline Symptoms Under Reboxetine Treatment

Ion Anghelescu, M.D.,
Britta Jänen, M.D.,
Frank Schindler, M.D., and
Claas-Hinrich Lammers, M.D., Department of Psychiatry, University Medicine Berlin, Germany

Pages:559–560
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.559

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November 2005

Hypergraphia for Poetry in an Epileptic Patient

Mario F. Mendez, M.D., Ph.D., Professor of Neurology and Psychiatry & Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA

Pages:560–561
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.560

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Correction

November 2005

Page:561
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.561

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Appreciation

November 2005

Pages:562–563
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.562

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Calendar

November 2005

Page:579
Published Online:1 November 2005

https://doi.org/10.1176/jnp.17.4.579

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