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The Journal of Neuropsychiatry and Clinical Neurosciences

Volume 10, Issue 1

February 1998

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Special Article

February 1998

The Clinician-Scientist in Neuropsychiatry

Jeffrey L. Cummings, M.D.,
C. Edward Coffey, M.D.,
James D. Duffy, M.D.,
Edward C. Lauterbach, M.D.,
Mark Lovell, Ph.D.,
Paul F. Malloy, Ph.D.,
Donald R. Royall, M.D.,
Teresa A. Rummans, M.D., and
Stephen Salloway, M.D., M.S.

Pages:1–9
Published Online:1 April 2006

https://doi.org/10.1176/jnp.10.1.1

Abstract
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Neuropsychiatric research seeks to improve the lives of patients with brain-based behavioral disturbances. There has been dramatic progress in diagnosis and treatment of neuropsychiatric disorders, and progress in neuroscience and biotechnology promises ...

February 1998

Neuropsychiatric Aspects of the Adult Variant of Tay-Sachs Disease

Glenda M. MacQueen, M.D., Ph.D., F.R.C.P.C.,
Patricia I. Rosebush, M.Sc.N., M.D., F.R.C.P.C., and
Michael F. Mazurek, M.D., F.R.C.P.C.

Pages:10–19
Published Online:1 April 2006

https://doi.org/10.1176/jnp.10.1.10

Abstract
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Tay-Sachs disease (a G_M2 gangliosidosis) is an inherited neuronal storage disease that can affect individuals across the age spectrum. Psychosis is reported in 30% to 50% of adult-onset patients, and many are misdiagnosed with schizophrenia. Mood ...

Regular Article

February 1998

The Use of Rapid-Rate Transcranial Magnetic Stimulation (rTMS) in Refractory Depressed Patients

Gary S. Figiel, M.D.,
Charles Epstein, M.D.,
William M. McDonald, M.D.,
Jody Amazon-Leece, M.S., G.N.P.,
Linda Figiel, R.N., M.S.N.,
Aida Saldivia, M.D., and
Susan Glover, M.D.

Pages:20–25
Published Online:1 April 2006

https://doi.org/10.1176/jnp.10.1.20

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Rapid-rate transcranial magnetic stimulation (rTMS) allows for the noninvasive examination of the cerebral cortex. Recent studies have begun to investigate whether rTMS may be therapeutic for the treatment of depression. In the present study, the authors ...

February 1998

Functional Impairment Associated With Acute Poststroke Depression

Rajamannar Ramasubbu, M.D., F.R.C.P.C.,
Robert G. Robinson, M.D.,
Alastair J. Flint, M.B., Ch.B., F.R.C.P.C., F.R.A.N.Z.C.P.,
Todd Kosier, B.S., and
Thomas R. Price, M.D.

Pages:26–33
Published Online:1 April 2006

https://doi.org/10.1176/jnp.10.1.26

Abstract
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To examine the independent association of depression following acute stroke with impairment in activities of daily living (ADL), the authors conducted a cross-sectional analysis of stroke patients enrolled in the Stroke Data Bank (U.S.A.) who had ...

February 1998

Effect of Anxiety Disorder on Impairment and Recovery From Stroke

Kengo Shimoda, M.D., and
Robert G. Robinson, M.D.

Pages:34–40
Published Online:1 April 2006

https://doi.org/10.1176/jnp.10.1.34

Abstract
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The effect of anxiety disorder on recovery from impairment following stroke was examined in 142 patients with acute stroke who had follow-up evaluations. Anxiety disorder significantly interacted with depression to influence the severity and course of ...

February 1998

Gender Differences in Poststroke Depression

Sergio Paradiso, M.D., Ph.D., and
Robert G. Robinson, M.D.

Pages:41–47
Published Online:1 April 2006

https://doi.org/10.1176/jnp.10.1.41

Abstract
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In stroke and other medical illnesses, secondary depression may be associated with different factors in women than in men. The authors examined 301 consecutive admissions for acute treatment of cerebrovascular accident for gender differences in depression,...

February 1998

Chronological Association Between Increases in Drug Abuse and Psychosis in Connecticut State Hospitals

Nashaat N. Boutros, M.D.,
Malcolm B. Bowers, Jr., M.D., and
Donald Quinlan, Ph.D.

Pages:48–54
Published Online:1 April 2006

https://doi.org/10.1176/jnp.10.1.48

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Disagreement remains as to whether drug use can result in an autonomous psychotic disorder. If drug use can create new psychosis cases, an increase in the number of psychosis patients ought to be observable following periods of increased drug use by the ...

February 1998

Differential Neuropsychiatric Symptom Responses to Tacrine in Alzheimer's Disease

Daniel Kaufer, M.D.,
Jeffrey L. Cummings, M.D., and
Dianne Christine, R.N.

Pages:55–63
Published Online:1 April 2006

https://doi.org/10.1176/jnp.10.1.55

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Neuropsychiatric symptom responses to tacrine were investigated in an open-label study of Alzheimer's outpatients. Forty subjects were stratified into three groups (Mild, Moderate, and Severe) based on Mini-Mental State Examination scores. A significant ...

February 1998

Olfactory Dysfunction Discriminates Alzheimer's Dementia From Major Depression

Gary S. Solomon, Ph.D.,
William M. Petrie, M.D.,
James R. Hart, M.D., and
Henry B. Brackin, Jr., M.D.

Pages:64–67
Published Online:1 April 2006

https://doi.org/10.1176/jnp.10.1.64

Abstract
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This study tested the hypothesis that olfactory dysfunction could discriminate between groups of patients with Alzheimer's disease and major depression. Forty patients meeting DSM-IV criteria for Alzheimer's disease and for major depression (20 per group) ...

February 1998

Determinants of SPontaneous Extrapyramidal Symptoms in Elderly Psychiatric Inpatients Diagnosed With Alzheimer's Disease, Major Depressive Disorder, or Psychotic Disorders

Robert A. Sweet, M.D.,
Mayada Akil, M.D.,
Benoit H. Mulsant, M.D.,
Richard Ulrich, M.S.,
Rona E. Pasternak, M.D., and
George S. Zubenko, M.D., Ph.D.

Pages:68–77
Published Online:1 April 2006

https://doi.org/10.1176/jnp.10.1.68

Abstract
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Extrapyramidal symptoms (EPS) occur more frequently in dementia of the Alzheimer's type (DAT) than in normal aging. Other late-life mental disorders, however, have also been associated with EPS. To examine whether EPS are increased in DAT patients ...

February 1998

Blood–Brain Barrier Integrity in Alzheimer's Disease Patients and Elderly Control Subjects

Maria T. Caserta, M.D., Ph.D.,
Daniel Caccioppo,
Gregory D. Lapin, Ph.D.,
Ann Ragin, Ph.D., and
Dennis R. Groothuis, M.D.

Pages:78–84
Published Online:1 April 2006

https://doi.org/10.1176/jnp.10.1.78

Abstract
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A defective blood–brain barrier (BBB) has been postulated to be present in Alzheimer's disease (AD), which would allow circulating β-amyloid peptide to enter the brain. The authors tested this hypothesis by studying BBB function in 14 individuals with ...

February 1998

The Motor Agitation and Retardation Scale

Christina Sobin, Ph.D.,
Laurel Mayer, M.D., and
Jean Endicott, Ph.D.

Pages:85–92
Published Online:1 April 2006

https://doi.org/10.1176/jnp.10.1.85

Abstract
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Increasing recognition of the neurologic aspects of depressive disorder has aroused new interest in the potential neuropathologic significance of “psychomotor” symptoms in depression. Psychomotor symptoms have yet to be clearly defined, however. The Motor ...

Clinical and Research Report

February 1998

Use of Clozapine in 10 Mentally Retarded Adults

Randall D. Buzan, M.D.,
Steven L. Dubovsky, M.D.,
Diane Firestone, R.N., C.F.N.P., and
Earlene Dal Pozzo, M.D.

Pages:93–95
Published Online:1 April 2006

https://doi.org/10.1176/jnp.10.1.93

Abstract
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The cost, side effect profile, and required weekly blood draws associated with clozapine may dissuade some clinicians from prescribing this atypical neuroleptic to mentally retarded patients. All publications on clozapine use in mentally retarded patients ...

February 1998

Is Olfactory Reference Syndrome an Obsessive-Compulsive Spectrum Disorder?

Dan J. Stein, M.B.,
Leon Le Roux, M.B.,
Colin Bouwer, M.B., and
Ben Van Heerden, M.B.

Pages:96–99
Published Online:1 April 2006

https://doi.org/10.1176/jnp.10.1.96

Abstract
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A number of disorders characterized by intrusive repetitive symptoms and varying degrees of insight may overlap phenomenologically and neurobiologically with obsessive-compulsive disorder (OCD). There is a question as to whether olfactory reference ...

February 1998

Prevalence of Alzheimer's Disease and Apolipoprotein E Allele Frequencies in the Old Order Amish

Jimmy Holder, B.A., and
Andrew C. Warren, M.B., B.S., D.Phil.

Pages:100–102
Published Online:1 April 2006

https://doi.org/10.1176/jnp.10.1.100

Abstract
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The authors examined the prevalence of Alzheimer's disease and apolipoprotein E allele frequencies in the Old Order Amish. A lower frequency of dementia in the Amish does not appear to be due to a reduced E4 frequency.

Neuropsychiatric Practice and Opinion

February 1998

Does Stroke Cause Depression?

Constantine G. Lyketsos, M.D., M.H.S.,
Glenn J. Treisman, M.D., Ph.D.,
John R. Lipsey, M.D.,
Philip L.P. Morris, M.D., and
Robert G. Robinson, M.D.

Pages:103–107
Published Online:1 April 2006

https://doi.org/10.1176/jnp.10.1.103

First Page
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Book Review

February 1998

The Psychiatry of Stroke

Andrew Hornstein, M.D.

Pages:109–110
Published Online:1 April 2006

https://doi.org/10.1176/jnp.10.1.109

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Letter

February 1998

Risperidone for the Treatment of Delusional Disorder Due to HIV Disease

Alia Maha, M.D., and
Kenneth Goetz, M.D., Allegheny General Hospital, Allegheny University of the Health Sciences, Pittsburgh, PA

Page:111
Published Online:1 April 2006

https://doi.org/10.1176/jnp.10.1.111

First Page
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February 1998

When Fluvoxamine Treats Only Depression and Clomipramine Treats Only Obsessive-Compulsive Disorder—Combine Them?

James L. Schaller, M.D., M.A.R., Life Counseling Professional Services, Paoli, PA,
David Behar, M.D., Eastern Pennsylvania Psychiatric Institute, Philadelphia, PA, and
Theodore J. Chamberlain, Ph.D., Eastern College, St. Davids, PA

Pages:111a–112
Published Online:1 April 2006

https://doi.org/10.1176/jnp.10.1.111a

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February 1998

Buspirone and Brain Injury

Jacob C. Holzer, M.D., Tufts School of Medicine, Boston, MA

Page:113
Published Online:1 April 2006

https://doi.org/10.1176/jnp.10.1.113

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February 1998

Affect and the Limbic System: Some Hard Problems

Douglas F. Watt, Ph.D., Director of Neuropsychology, Quincy Hospital, Quincy, MA

Pages:113a–116
Published Online:1 April 2006

https://doi.org/10.1176/jnp.10.1.113a

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February 1998

Obsessive-Compulsive Disorder, Tourette's Syndrome, and Basal Ganglia Pathology on MRI

Philip R. Saba, M.D.,
Khurshed Dastur, M.D.,
M. Reza Raji, M.D., Department of Radiology, Mercy Hospital of Pittsburgh, Pittsburgh, PA,
Matcheri S. Keshavan, M.D., Western Psychiatric Institute and Clinic, Pittsburgh, PA, and
M. Ammar Katerji, M.D., Department of Pediatric Neurology, Mercy Hospital of Pittsburgh

Pages:116–117
Published Online:1 April 2006

https://doi.org/10.1176/jnp.10.1.116

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February 1998

Palicoprolalia: An Unusual Variant of Palilalia in Gilles de la Tourette's Syndrome

Jordi Serra-Mestres, L.M.S., M.R.C.Psych.,
Mary M. Robertson, M.B., Ch.B., M.D., D.P.M., F.R.C.Psych., Institute of Neurology, Queen Square, London, England, and
Teena Shetty, A.B., Brown University School of Medicine, Providence, RI

Pages:117–118
Published Online:1 April 2006

https://doi.org/10.1176/jnp.10.1.117

Full text
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