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The Journal of Neuropsychiatry and Clinical Neurosciences

Volume 10, Issue 2

May 1998

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Special Article

May 1998

Mild Cognitive Impairment and Risk of Mortality in HIV-1 Infection

Frances L. Wilkie, Ph.D.,
Karl Goodkin, M.D., Ph.D.,
Carl Eisdorfer, M.D., Ph.D.,
Daniel Feaster, M.S.,
Robert Morgan, Ph.D.,
Mary Ann Fletcher, Ph.D.,
Nancy Blaney, Ph.D.,
Marianna Baum, Ph.D., and
Jose Szapocznik, Ph.D.

Pages:125–132
Published Online:1 May 1998

https://doi.org/10.1176/jnp.10.2.125

Abstract
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HIV-1–associated cognitive impairment has only been preliminarily investigated for associations with mortality. The authors examined 119 HIV-1–positive homosexual men (asymptomatic: n=96; early symptomatic: n=23). At follow-up (to 3.5 years), there were ...

May 1998

Magnetic Resonance Spectroscopy in Affective Disorders

Tadafumi Kato, M.D.,
Toshiro Inubushi, Ph.D., and
Nobumasa Kato, M.D., Ph.D.

Pages:133–147
Published Online:1 May 1998

https://doi.org/10.1176/jnp.10.2.133

Abstract
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Magnetic resonance spectroscopy (MRS) is a noninvasive tool for in vivo chemical analysis that has been applied to neurobiological or psychopharmacological studies of affective disorders. Studies employing ³¹P-MRS and ¹H-MRS have indicated possible ...

May 1998

Selective Pharmacological Activation of Limbic Structures in Human Volunteers

David Servan-Schreiber, M.D., Ph.D.,
William M. Perlstein, Ph.D.,
Jonathan D. Cohen, M.D., Ph.D., and
Mark Mintun, M.D.

Pages:148–159
Published Online:1 May 1998

https://doi.org/10.1176/jnp.10.2.148

Abstract
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Using a pharmacological probe, procaine hydrochloride, the authors elicited consistent and selective activation of anterior limbic and paralimbic structures in normal human volunteers as documented by H₂¹⁵O positron emission tomography. This activation ...

Regular Article

May 1998

Frontal Systems Dysfunction in Children With Attention-Deficit/Hyperactivity Disorder and Learning Disabilities

J. Wayne Lazar, Ph.D., and
Yitzchak Frank, M.D.

Pages:160–167
Published Online:1 May 1998

https://doi.org/10.1176/jnp.10.2.160

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Tests of attention, inhibition, working memory, motor learning, and problem solving—functions associated with the brain's frontal systems—were administered to 26 children with attention-deficit/hyperactivity disorder and learning disabilities (ADHD+LD), ...

May 1998

Age-Related Changes in Brain Glucose Metabolism in Adults With Attention-Deficit/Hyperactivity Disorder and Control Subjects

Monique Ernst, M.D., Ph.D.,
Alan J. Zametkin, M.D.,
Robert L. Phillips, Ph.D., and
Robert M. Cohen, M.D., Ph.D.

Pages:168–177
Published Online:1 May 1998

https://doi.org/10.1176/jnp.10.2.168

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Using positron emission tomography and [¹⁸F]-2-fluoro-2-deoxy-d-glucose, the authors determined cerebral metabolic rates for glucose (CMRglc) in 39 adults (18–51 years old) with attention-deficit/hyperactivity disorder (ADHD) and 56 healthy control ...

May 1998

Changes in Seizure Threshold Over the Course of Electroconvulsive Therapy Affect Therapeutic Response and Are Detected by Ictal EEG Ratings

Andrew D. Krystal, M.D., M.S.,
C. Edward Coffey, M.D.,
Richard D. Weiner, M.D., Ph.D., and
Tracey Holsinger, M.D.

Pages:178–186
Published Online:1 May 1998

https://doi.org/10.1176/jnp.10.2.178

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Therapeutic effectiveness of electroconvulsive therapy is influenced by the degree to which the stimulus intensity exceeds the seizure threshold. However, the threshold rises variably over the treatment course, confounding maintenance of desired relative ...

May 1998

Effectiveness of ECT in Patients With Parkinsonism

Chris Moellentine, M.D.,
Teresa Rummans, M.D.,
J. Eric Ahlskog, Ph.D., M.D.,
William S. Harmsen, M.S.,
Vera J. Suman, Ph.D.,
M. Kevin O'Connor, M.D.,
John L. Black, M.D., and
Thomas Pileggi, R.N.

Pages:187–193
Published Online:1 May 1998

https://doi.org/10.1176/jnp.10.2.187

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Electroconvulsive therapy (ECT) has been used to treat the psychiatric complications of Parkinson's disease. Concurrent improvement of parkinsonian motor symptoms has been noted. This retrospective study compared the outcomes of 25 patients with ...

May 1998

Delusional Misidentification in Association With Parkinsonism

David M. Roane, M.D.,
John D. Rogers, M.D.,
Jessica H. Robinson, and
Todd E. Feinberg, M.D.

Pages:194–198
Published Online:1 May 1998

https://doi.org/10.1176/jnp.10.2.194

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The delusional misidentification syndrome (DMS) has been associated with a range of neurological conditions. Three cases of DMS in patients with Parkinson's disease and dementia, treated with dopaminergic medications, are presented. It is postulated that ...

May 1998

Is Delirium Different When It Occurs in Dementia?

Paula T. Trzepacz, M.D.,
Benoit H. Mulsant, M.D.,
Mary Amanda Dew, Ph.D.,
Rona Pasternak, M.D.,
Robert A. Sweet, M.D., and
George S. Zubenko, M.D., Ph.D.

Pages:199–204
Published Online:1 May 1998

https://doi.org/10.1176/jnp.10.2.199

Abstract
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The authors studied 61 geropsychiatric patients with delirium from a cohort of 843 consecutive admissions to a geriatric clinical research unit. A central study goal was to assess how the presence of dementia affected the presentation of delirium. ...

May 1998

Cognitive Decline in Patients on an Acute Geropsychiatric Unit

Dolon Das, MS,
Claudia A. Orengo, M.D., Ph.D.,
Mark E. Kunik, M.D.,
Victor Molinari, Ph.D., and
Richard H. Workman, M.D.

Pages:205–209
Published Online:1 May 1998

https://doi.org/10.1176/jnp.10.2.205

Abstract
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The authors compared patients in a geropsychiatric unit who showed marked cognitive decline during hospitalization with those who did not. Patients who declined in cognitive function were older, were more likely to have a diagnosis of dementia, and were ...

May 1998

Subtle Neurological Deficits and Psychopathological Findings in Substance-Abusing Homeless and Non-Homeless Veterans

Richard Douyon, M.D.,
Paul Guzman, M.D.,
Gerard Romain, M.D.,
Susan J. Ireland, Ph.D.,
Lourdes Mendoza, M.D.,
Marino Lopez-Blanco, M.S.W., and
Fernando Milanes, M.D.

Pages:210–215
Published Online:1 May 1998

https://doi.org/10.1176/jnp.10.2.210

Abstract
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This study evaluated the hypothesis that homeless individuals would display higher levels of neurological deficits than non-homeless individuals, particularly in frontal lobe or executive functions. Eighteen acutely homeless, 15 chronically homeless, and ...

Clinical and Research Report

May 1998

Quetiapine (Seroquel) in the Treatment of Psychosis in Patients With Parkinson's Disease

Mahmoud A. Parsa, M.D., and
Bijan Bastani, M.D.

Pages:216–219
Published Online:1 May 1998

https://doi.org/10.1176/jnp.10.2.216

Abstract
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Psychoses are a common clinical problem in patients with Parkinson's disease. Treatment with typical neuroleptics or withdrawal of antiparkinsonian drugs may improve mental symptoms but will worsen the parkinsonism. Quetiapine (Seroquel), ICI 204,636, is ...

May 1998

Risperidone for the Treatment of Behavioral Disturbances in Dementia

Nathan Herrmann, M.D., F.R.C.P.C.,
Marie-France Rivard, M.D., F.R.C.P.C.,
Michael Flynn, M.D., F.R.C.P.C.,
Carol Ward, M.D., F.R.C.P.C.,
Kiran Rabheru, M.D., F.R.C.P.C., and
Barry Campbell, M.D., F.R.C.P.C.

Pages:220–223
Published Online:1 May 1998

https://doi.org/10.1176/jnp.10.2.220

Abstract
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The authors describe a series of 22 patients with dementia and behavioral disturbances, including agitation, aggression, delusions, and hallucinations, who were treated with risperidone. Risperidone, in low doses, was well tolerated; 50% of patients ...

May 1998

A Preliminary Study of d-Cycloserine Treatment in Alzheimer's Disease

Guochuan E. Tsai, M.D., Ph.D.,
William E. Falk, M.D., and
Jeanette Gunther, M.S.

Pages:224–226
Published Online:1 May 1998

https://doi.org/10.1176/jnp.10.2.224

Abstract
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d-cycloserine is a partial agonist on the glycine site of the N-methyl-d-aspartate glutamate receptor. This double-blind crossover study of 15 mg d-cycloserine in Alzheimer's disease patients did not demonstrate clinical benefit. Higher medication dosage ...

May 1998

Neuroleptic Sensitivity to Clozapine in Dementia With Lewy Bodies

William J. Burke, M.D.,
Ronald F. Pfeiffer, M.D., and
Rodney D. McComb, M.D.

Pages:227–229
Published Online:1 May 1998

https://doi.org/10.1176/jnp.10.2.227

Abstract
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Dementia with Lewy bodies (DLB) may be one of the most common causes of dementia. It should be of particular interest to psychiatrists because hallucinations are common presenting symptoms and because patients with DLB may be particularly sensitive to ...

Classic Article

May 1998

Hans Selye and the Field of Stress Research

Thomas C. Neylan, M.D., Section Editor

Page:230
Published Online:1 May 1998

https://doi.org/10.1176/jnp.10.2.230

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May 1998

A Syndrome Produced by Diverse Nocuous Agents

Hans Selye

Pages:230a–231
Published Online:1 May 1998

https://doi.org/10.1176/jnp.10.2.230a

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Book Review

May 1998

Handbook of Psychiatric Genetics

Wilfrid Noel Raby, M.D., Ph.D.

Pages:232–233
Published Online:1 May 1998

https://doi.org/10.1176/jnp.10.2.232

First Page
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May 1998

Neuropsychological Rehabilitation: Fundamentals, Innovations and Directions

George J. Carnevale, Ph.D.

Pages:233–234
Published Online:1 May 1998

https://doi.org/10.1176/jnp.10.2.233

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Letter

May 1998

Treatment of a Case of Comorbid Bipolar Disorder and Attention-Deficit/Hyperactivity Disorder

James L. Schaller, M.D., West Chester, PA, and
David Behar, M.D., Philadelphia, PA

Pages:235–236
Published Online:1 May 1998

https://doi.org/10.1176/jnp.10.2.235

First Page
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May 1998

Acute Psychosis Associated With Butorphanol

Amanda Davis,
Beth Yudofsky, M.D., and
Saleem Quidwai, M.D., Consultation and Liaison Psychiatry Service, Ben Taub General Hospital, Houston, TX

Pages:236–237
Published Online:1 May 1998

https://doi.org/10.1176/jnp.10.2.236

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May 1998

Organic Catatonia Following Frontal Lobe Injury: Response to Clozapine

Oliver Rommel, M.D.,
Martin Tegenthoff, M.D.,
Walter Widdig, Ph.D.,
Peter BrÄUnig, M.D., and
Jean-Pierre Malin, M.D., University Departments of Clinical Neurology and Psychiatry, Ruhr-University Bochum, BG-Kliniken Bergmannsheil, Germany

Pages:237–238
Published Online:1 May 1998

https://doi.org/10.1176/jnp.10.2.237

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